|(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-乙氧基-3,6,9-三甲基十氢-3H-3,12-环氧[1,2]dioxepino[4,3-i]异苯并呋喃|CsnPharm

CAS No.: 75887-54-6

蒿乙醚 Catalog No. CSN10339

Synonyms: 蒿乙醚;β-Arteether;(+)-Arteether

Arteether is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases.

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生物活性

描述Arteether is a artemisinin derivative that is oil soluble, has a long elimination half life, and is more stable than other derivatives used in severe malaria^[3]. Arteether (ART), an artemisinin derivative, is effective against Plasmodium falciparum, but it is available only as painful oily intramuscular (i.m.) injections^[4]. Arteether at 50 mg kg-1 × 1, 25 mg kg-1 × 2, days decreased the NMDAR (N-methyl-D-aspartate receptors) expression and increased the overall survival of the experimental CM (Cerebral Malaria) mice^[5]. Multiple doses of arteether (ARTE) at 25 mg/kg cause CNS and anorectic toxicities in rats. Acute toxicity data of artemisinin drugs demonstrated that animals receiving a high single ARTE dose in sesame oil died between days 5-11, similar to artemether^[6]. In addition, ARE (Arteether) could reduce the cell growth of 4T1 cell line in a dose-dependent manner but it had no cytotoxic effect on the growth of peripheral blood lymphocytes^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03093129	Colorectal Cancer	Phase 2	Recruiting	December 2022	Vietnam ... more >> 108 Military Central Hospital Recruiting Hanoi, Vietnam Contact: Le Huu Song, MD, PhD +84 (0) 974845270 lehuusong@108-icid.com Contact: Bui Tien Sy, MD, PhD +84 (0) 974552943 tiensy2015@yahoo.com Principal Investigator: Le Huu Song, MD, PhD Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2010 mL
- 16.0051 mL
- 32.0101 mL
- 5 mM
- 0.6402 mL
- 3.2010 mL
- 6.4020 mL
- 10 mM
- 0.3201 mL
- 1.6005 mL
- 3.2010 mL

技术信息

CAS号

75887-54-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H28O5

运输

蓝冰

分子量

312.40

别名

蒿乙醚;β-Arteether;(+)-Arteether;Arteether;蒿甲醚

溶解度

DMSO	59.0 mg/mL (188.9 mM)

动物实验配方

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